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Title   소세포 폐암에서 CAV 및 EP 복합화학요법의 교대 치료 성적 ( Alternating Non-Cross-Resistant Chemotherapy with CAV ( Cyclophosphamide , Adriamycin , Vincristine ) and EP ( Etoposide , Cisplatin ) in Small Cell Lung Cancer )
Publicationinfo   1992 Jan; 024(04): 570-577.
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Abstract   Fifty-three patients with small cell lung cancer were treated with chemotherapy consisting of cyclophosphamide, adriamycin, and vincristine(CAV) alternating with etoposide and cisplatin(EP). Thoracic radiotherapy was administered to the patients with limited stage disease. Prophylactic cranial irradiation with 30 Gy was applied to all complete responders. Overall response rate was 66% with 32% of complete response. The response rate was 78% (CR 4l%, PR 37%) in the patients with limited stage disease, and 54%(CR 23%, PR 31%) in those with extensive stage disease. Patients with good performance score(ECOG 0-l) showed higher response rate sign ificantly(p = 0.003). Overall median survival was 8 months(2 37+). And the median survival in patients with CR, PR, and no response(SD and PD) were 12, 7.5, and 4 months, respectively(p<0.01). These results suggest that alternating chemotherapy with CAV and EP may be useful as a treatment strategy in small cell lung cancer, but deserves more intensive randomized trials.
저 자   손창학(Chang Hak Sohn),이봉춘(Bong Choon Lee),신형규(Hyoung Kyu Chin),조기정(Key Jung Cho)